Subtle changes in perivascular endometrial mesenchymal stem cells after local endometrial injury in recurrent implantation failure.

ABSTRACT: Improvements in reproductive techniques have resulted in the live birth rates from IVF procedures increasing from 5% to approximately 30% in recent decades but has plateaued since. Emerging preclinical and clinical data implicates endometrial receptivity deficiencies in patients with recurrent implantation failure (RIF) as the predominant factor hindering successful implantation. Mechanisms on how local endometrial injury (LEI) improves implantation rates in patients with RIF are currently unknown. We hypothesized that LEI may influence perivascular endometrial mesenchymal stem/progenitor cells (eMSCs) which are thought to regenerate the stromal vascular component of the functional layer every month. Here, we assessed the effect of LEI on the proportion and function of eMSCs present in con

SUBMITTER: Fan Y 

PROVIDER: S-EPMC9816312 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature