Prospective Study of Perioperative Circulating Tumor DNA Dynamics in Patients Undergoing Hepatectomy for Colorectal Liver Metastases.

ABSTRACT:

Objective

To evaluate the association of perioperative ctDNA dynamics on outcomes after hepatectomy for CLM.

Summary background data

Prognostication is imprecise for patients undergoing hepatectomy for CLM, and ctDNA is a promising biomarker. However, clinical implications of perioperative ctDNA dynamics are not well established.

Methods

Patients underwent curative-intent hepatectomy after preoperative chemotherapy for CLM (2013-2017) with paired prehepatectomy/postoperative ctDNA analyses via plasma-only assay. Positivity was determined using a proprietary variant classifier. Primary endpoint was recurrence-free survival (RFS). Median follow-up was 55 months.

Results

Forty-eight patients were included. ctDNA was detected before and after surgery (ctDNA+/+) in

SUBMITTER: Newhook TE 

PROVIDER: S-EPMC9816346 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature