High MBL-expressing genotypes are associated with deterioration in renal function in type 2 diabetes.

ABSTRACT:

Introduction

Accumulating evidence support that mannan-binding lectin (MBL) is a promising prognostic biomarker for risk-stratification of diabetic micro- and macrovascular complications. Serum MBL levels are predominately genetically determined and depend on MBL genotype. However, Type 1 diabetes (T1D) is associated with higher MBL serum levels for a given MBL genotype, but it remains unknown if this is also the case for patients with T2D. In this study, we evaluated the impact of MBL genotypes on renal function trajectories serum MBL levels and compared MBL genotypes in newly diagnosed patients with T2D with age- and sex-matched healthy individuals. Furthermore, we evaluated differences in parameters of insulin resistance within MBL genotypes.

Methods

In a cross-sectional

SUBMITTER: Dorflinger GH 

PROVIDER: S-EPMC9816478 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature