COVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy.

ABSTRACT: Severe neurological symptoms are associated with Coronavirus disease 2019 (COVID-19). However, the morphologic features, pathological nature and their potential mechanisms in patient brains have not been revealed despite evidence of neurotropic infection. In this study, neuropathological damages and infiltrating inflammatory cells were quantitatively evaluated by immunohistochemical staining, ultrastructural examination under electron microscopy, and an image threshold method, in postmortem brains from nine critically ill COVID-19 patients and nine age-matched cadavers of healthy individuals. Differentially expressed proteins were identified by quantitative proteomic assays. Histopathological findings included neurophagocytosis, microglia nodules, satellite phenomena, extensive edema, foca

SUBMITTER: Zhang PP 

PROVIDER: S-EPMC9816522 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature