Magnetic resonance-based radiomics nomogram for predicting microsatellite instability status in endometrial cancer.

ABSTRACT:

Background

Microsatellite instability (MSI) status is an important indicator for screening patients with endometrial cancer (EC) who have potential Lynch syndrome (LS) and may benefit from immunotherapy. This study aimed to develop a magnetic resonance imaging (MRI)-based radiomics nomogram for the prediction of MSI status in EC.

Methods

A total of 296 patients with histopathologically diagnosed EC were enrolled, and their MSI status was determined using immunohistochemical (IHC) analysis. Patients were randomly divided into the training cohort (n=236) and the validation cohort (n=60) at a ratio of 8:2. To predict the MSI status in EC, the tumor radiomics features were extracted from T2-weighted images and contrast-enhanced T1-weighted images, which in turn were selected usi

SUBMITTER: Lin Z 

PROVIDER: S-EPMC9816750 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature