Convulsive behaviors of spontaneous recurrent seizures in a mouse model of extended hippocampal kindling.

ABSTRACT: Growing studies indicate that vigilance states and circadian rhythms can influence seizure occurrence in patients with epilepsy and rodent models of epilepsy. Electrical kindling, referred to brief, repeated stimulations of a limbic structure, is a commonly used model of temporal lobe epilepsy. Kindling via the classic protocol lasting a few weeks does not generally induce spontaneous recurrent seizures (SRS), but extended kindling that applies over the course of a few months has shown to induce SRS in several animal species. Kindling-induced SRS in monkeys and cats were observed mainly during resting wakefulness or sleep, but the behavioral activities associated with SRS in rodent models of extended kindling remain unknown. We aimed to add information in this area using a mouse mod

SUBMITTER: Zahra A 

PROVIDER: S-EPMC9816810 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature