Raltitrexed as a substitute for capecitabine in metastatic gastric cancer: a case report and literature review.

ABSTRACT:

Background

5-Fluorouracil and its oral prodrug, capecitabine, are frequently used in the treatment of gastrointestinal cancers-including gastric cancer-but carry a cardiotoxicity risk. Raltitrexed (brand name Tomudex), a direct inhibitor of thymidylate synthase, has been successfully used as an alternative to fluoropyrimidines in patients with 5-fluorouracil-induced cardiac events. We report the first case, to our knowledge, of raltitrexed used with trastuzumab and platinum-based chemotherapy as a substitute for fluoropyrimidines following cardiotoxicity in a 78-year-old male patient with metastatic gastric cancer.

Case description

The patient experienced a myocardial infarction 3 days after beginning treatment with capecitabine, carboplatin, and trastuzumab for metastatic H

SUBMITTER: Ladak I 

PROVIDER: S-EPMC9816848 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature