Association of <i>CYP2D6</i> genotype predicted phenotypes with oxycodone requirements and side effects in children undergoing surgery.

ABSTRACT:

Background

Oxycodone is a commonly used oral opioid in children for treating postoperative pain. Highly polymorphic gene CYP2D6 metabolizes oxycodone into its more potent metabolite, oxymorphone. We hypothesized that altered activity due to CYP2D6 polymorphisms will influence oxycodone requirements {relative oxycodone use [oxycodone morphine equivalents (MEq)/total MEq] to maintain analgesia} (primary outcome) and risk for oxycodone induced side-effects such as respiratory depression (RD) and emesis (secondary outcomes). We also explored the influence of genotype availability and provider guidance on oral opioid prescription patterns.

Methods

Patients who underwent Nuss procedure and spine fusion with CYP2D6 genotyping results available preoperatively we

SUBMITTER: Merchant S 

PROVIDER: S-EPMC9816853 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature