Gut microbiota and transcriptome profiling revealed the protective effect of aqueous extract of <i>Tetrastigma hemsleyanum</i> leaves on ulcerative colitis in mice.

ABSTRACT: Tetrastigma hemsleyanum, a traditional Chinese medicinal plant, possesses various biological activities, including anti-inflammatory and immunomodulatory functions. The purpose of this study was to determine the alleviating effect of the water extract of Tetrastigma hemsleyanum leaves (THLW) on ulcerative colitis (UC) and its relationship with gut microbiota. The administration of THLW significantly decreased the severity of dextran sulfate sodium (DSS)-induced intestinal damage, as demonstrated by the stabilization of body weight and colon length, and decreased disease activity index (DAI) and histological scores. THLW also decreased NF-κB protein expression in colon tissues and reduced the serum levels of IL-6, IL-1β, and TNF-α. Further co-housing experiment confirmed that

SUBMITTER: Wang J 

PROVIDER: S-EPMC9816909 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature