Microscale multicircuit brain stimulation: Achieving real-time brain state control for novel applications.

ABSTRACT: Neurological and psychiatric disorders typically result from dysfunction across multiple neural circuits. Most of these disorders lack a satisfactory neuromodulation treatment. However, deep brain stimulation (DBS) has been successful in a limited number of disorders; DBS typically targets one or two brain areas with single contacts on relatively large electrodes, allowing for only coarse modulation of circuit function. Because of the dysfunction in distributed neural circuits - each requiring fine, tailored modulation - that characterizes most neuropsychiatric disorders, this approach holds limited promise. To develop the next generation of neuromodulation therapies, we will have to achieve fine-grained, closed-loop control over multiple neural circuits. Recent work has demonstrated spati

SUBMITTER: Saalmann YB 

PROVIDER: S-EPMC9816916 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature