Comparison of the Single-Cell Immune Landscape of Testudines from Different Habitats.

ABSTRACT: Testudines, also known as living fossils, have evolved diversely and comprise many species that occupy a variety of ecological niches. However, the immune adaptation of testudines to the different ecological niches remains poorly understood. This study compared the composition, function, and differentiation trajectories of peripheral immune cells in testudines (Chelonia mydas, Trachemys scripta elegans, Chelonoidis carbonaria, and Pelodiscus sinensis) from different habitats using the single-cell RNA sequencing (scRNA-seq) technique. The results showed that T. scripta elegans, which inhabits freshwater and brackish environments, had the most complex composition of peripheral immune cells, with 11 distinct immune cell subsets identified in total. The sea t

SUBMITTER: Guo R 

PROVIDER: S-EPMC9816942 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature