Splenic arterial neurovascular bundle stimulation in esophagectomy: A feasibility and safety prospective cohort study.

ABSTRACT:

Introduction

The autonomic nervous system is a key regulator of inflammation. Electrical stimulation of the vagus nerve has been shown to have some preclinical efficacy. However, only a few clinical studies have been reported to treat inflammatory diseases. The present study evaluates, for the first time, neuromodulation of the splenic arterial neurovascular bundle (SpA NVB) in patients undergoing minimally invasive esophagectomy (MIE), in which the SpA NVB is exposed as part of the procedure.

Methods

This single-center, single-arm study enrolled 13 patients undergoing MIE. During the abdominal phase of the MIE, a novel cuff was placed around the SpA NVB, and stimulation was applied. The primary endpoint was the feasibility and safety of cuff application and removal. A secon

SUBMITTER: Brinkman DJ 

PROVIDER: S-EPMC9817142 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature