Bacteroides-derived isovaleric acid enhances mucosal immunity by facilitating intestinal IgA response in broilers.

ABSTRACT:

Background

The interaction between nutrition and immunity plays a vital role in nutrient digestion, absorption, and metabolism during poultry production. Recent studies showed that the gut microbiota contributes to the development of intestinal mucosal immunity. However, the mechanisms by which gut microbes regulate this process remain unclear.

Methods

We compared the intestinal mucosal immunity and gut microbiota of Arbor Acre broilers (AA (lower mucosal immunity) and Chinese native Wuliang Mountain Black-bone chickens (WLMB) (higher mucosal immunity) using 16S rDNA sequencing, transcriptomic analysis, and immunoglobulin A (IgA) antibody repertoire sequencing. We then combined 16S rDNA sequencing with transcriptomics to identify the key microbes and found that they were pos

SUBMITTER: Wang X 

PROVIDER: S-EPMC9817248 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature