Expression of factor XIII originating from synovial fibroblasts and macrophages induced by interleukin-6 signaling.

ABSTRACT:

Background

Blood coagulation factor XIII (FXIII) promotes cross-linking between fibrin molecules at the final stage of the blood coagulation cascade. However, its expression in cells or tissues and function, particularly factor XIII subunit B (FXIII-B), remains controversial. Hemorrhagic FXIII deficiency following anti-interleukin-6 (IL-6) receptor antibody treatment has been reported in patients with rheumatoid arthritis (RA). Patients receiving this biologics have reduced FXIII activity when compared to the activity in those treated with other biologics. The relationship between pro-inflammatory cytokines and FXIII expression remains unknown.

Methods

To investigate the expression pattern of FXIII in synovial tissues, immunohistochemistry, RT-qPCR, and western blotting were

SUBMITTER: Watanabe H 

PROVIDER: S-EPMC9817275 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature