Gut microbiome and stages of diabetes in middle-aged adults: CARDIA microbiome study.

ABSTRACT:

Background

Animal and human studies suggest the gut microbiome is linked to diabetes but additional data are needed on the associations of the gut microbiome to specific diabetes characteristics. The aim of this study was to examine the associations of gut microbiome composition to insulin resistance [Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)], duration of diabetes, and 4 stages of diabetes [normoglycemia, pre-diabetes, and diabetes with (+) and without (-) medication for diabetes].

Methods

Data are from a sub-sample (n = 605) of Black and White participants from the 30-year follow-up exam of the prospectively followed community-based Coronary Artery Risk Development in Young Adults cohort (2015-2016; aged 48-60 years). Stool samples were collected and seq

SUBMITTER: Hu YH 

PROVIDER: S-EPMC9817375 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature