Bleomycin-induced lung injury: Revisiting an old tool to model group III PH associated with pulmonary fibrosis.

ABSTRACT: Pulmonary hypertension (PH) is a chronic disorder of the pulmonary circulation that often associates with other respiratory diseases (i.e., group III PH), leading to worsened symptoms and prognosis, notably when combined with interstitial lung diseases such as pulmonary fibrosis (PF). PH may lead to right ventricular (RV) failure, which accounts for a substantial part of the mortality in chronic lung disease patients. The disappointing results of pulmonary arterial hypertension (PAH)-related therapies in patients with PF emphasize the need to better understand the pathophysiologic mechanisms that drive PH development and progression in this specific setting. In this work, we validated an animal model of group III PH associated with PF (PH-PF), by using bleomycin (BM) intratracheal instilla

SUBMITTER: Santos-Ribeiro D 

PROVIDER: S-EPMC9817427 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature