Cancer Cells Upregulate Tau to Gain Resistance to DNA Damaging Agents

ABSTRACT:

Simple Summary

The role of Tau in genome protection and/or repair in neurons suggests that Tau expression in cancer cells could be involved in resistance to conventional anti-cancer treatments, in particular those inducing DNA damage. Knockdown of Tau in breast cancer cell lines improved the cellular response and resulted in a significant decrease of mouse-xenograft breast tumor volume after DNA damaging agent treatments by impairing the classical nonhomologous end-joining pathway. Tau allows 53BP1 to translocate to the nucleus in response to DNA damage by chaperoning microtubule protein trafficking.

Abstract

Recent reports suggested a role for microtubules in double-strand-DNA break repair. We herein investigated the role of the microtubule-associated protein Tau in radi

SUBMITTER: Rico T 

PROVIDER: S-EPMC9817522 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature