Hsa_circ_0015278 Regulates FLT3-ITD AML Progression via Ferroptosis-Related Genes

ABSTRACT:

Simple Summary

Acute myeloid leukemia (AML), especially the FLT3-ITD mutation subtype, has a poorer prognosis and higher risk of recurrence, which seriously threatens human health. Ferroptosis, an iron-dependent regulated cell death, is involved in the development and progression of AML. The mechanism by which circRNAs regulate the pathogenesis and prognosis of FLT3-ITD mutant-type AML through ferroptosis-related genes (FerRGs) remains unclear. In the present study, we aimed to decipher the pathogenic role of circRNAs in AML with FLT3-ITD mutation. Encouragingly, we discovered a circRNA, hsa_circ_0015278, that regulates ferroptosis-related genes by sponging miRNAs to promote FLT3-ITD AML progression. Furthermore, ferroptosis-related genes with prognostic value contribute to FLT3-I

SUBMITTER: Jiang J 

PROVIDER: S-EPMC9817690 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature