The FDA-Approved Drug Pyrvinium Selectively Targets ER⁺ Breast Cancer Cells with High INPP4B Expression.

ABSTRACT: The majority of breast cancers are estrogen receptor-positive (ER⁺), and endocrine therapies that suppress ER signaling are the standard-of-care treatment for this subset. However, up to half of all ER⁺ cancers eventually relapse, highlighting a need for improved clinical therapies. The phosphoinositide phosphatase, INPP4B, is overexpressed in almost half of all ER⁺ breast cancers, and promotes Wnt/β-catenin signaling, cell proliferation and tumor growth. Here, using cell viability assays, we report that INPP4B overexpression does not affect the sensitivity of ER⁺ breast cancer cells to standard-of-care treatments including the anti-estrogen 4-hydroxytamoxifen (4-OHT) or the PI3Kα inhibitor alpelisib. Examination of four small molecule Wnt inhibi

SUBMITTER: Rodgers SJ 

PROVIDER: S-EPMC9817693 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature