5-Azacytidine-Mediated Modulation of the Immune Microenvironment in Murine Acute Myeloid Leukemia

ABSTRACT:

Simple Summary

Leukemic growth results in selective silencing of gene transcripts involved in immune detection, differentiation, and apoptosis. Hypomethylating agents (HMAs), such as 5-azacytidine, have been shown to reprogram the genetic landscape in various cancers to restore both transgene and endogenous transcript expression. In this study, we show that 5-azacytidine treatment re-establishes both luciferase (transgene) and immune-related (endogenous) transcript expression in murine leukemia models, highlighting the broad applicability of HMAs in rescuing tumor suppressor and tumor antigen gene expression and enhancing cancer susceptibility to immunity. In addition, the immune microenvironment undergoes alterations after 5-azacytidine treatment, giving additional insight into t

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PROVIDER: S-EPMC9817798 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature