CRAC and SK Channels: Their Molecular Mechanisms Associated with Cancer Cell Development.

ABSTRACT: Cancer represents a major health burden worldwide. Several molecular targets have been discovered alongside treatments with positive clinical outcomes. However, the reoccurrence of cancer due to therapy resistance remains the primary cause of mortality. Endeavors in pinpointing new markers as molecular targets in cancer therapy are highly desired. The significance of the co-regulation of Ca²⁺-permeating and Ca²⁺-regulated ion channels in cancer cell development, proliferation, and migration make them promising molecular targets in cancer therapy. In particular, the co-regulation of the Orai1 and SK3 channels has been well-studied in breast and colon cancer cells, where it finally leads to an invasion-metastasis cascade. Nevertheless, many questions remain unanswered,

SUBMITTER: Tiffner A 

PROVIDER: S-EPMC9817886 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature