Effects of Microbeam Irradiation on Rodent Esophageal Smooth Muscle Contraction.

ABSTRACT:

Background

High-dose-rate radiotherapy has shown promising results with respect to normal tissue preservation. We developed an ex vivo model to study the physiological effects of experimental radiotherapy in the rodent esophageal smooth muscle.

Methods

We assessed the physiological parameters of the esophageal function in ex vivo preparations of the proximal, middle, and distal segments in the organ bath. High-dose-rate synchrotron irradiation was conducted using both the microbeam irradiation (MBI) technique with peak doses greater than 200 Gy and broadbeam irradiation (BBI) with doses ranging between 3.5-4 Gy.

Results

Neither MBI nor BBI affected the function of the contractile apparatus. While peak latency and maximal force change were not affected in the BBI group

SUBMITTER: Frerker B 

PROVIDER: S-EPMC9818134 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature