Molecular Mechanisms and Clinical Application of Multipotent Stem Cells for Spinal Cord Injury.

ABSTRACT: Spinal Cord Injury (SCI) is a common neurological disorder with devastating psychical and psychosocial sequelae. The majority of patients after SCI suffer from permanent disability caused by motor dysfunction, impaired sensation, neuropathic pain, spasticity as well as urinary complications, and a small number of patients experience a complete recovery. Current standard treatment modalities of the SCI aim to prevent secondary injury and provide limited recovery of lost neurological functions. Stem Cell Therapy (SCT) represents an emerging treatment approach using the differentiation, paracrine, and self-renewal capabilities of stem cells to regenerate the injured spinal cord. To date, multipotent stem cells including mesenchymal stem cells (MSCs), neural stem cells (NSCs), and hematopoieti

SUBMITTER: Szymoniuk M 

PROVIDER: S-EPMC9818156 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature