Blood Plasma Metabolome Profiling at Different Stages of Renal Cell Carcinoma

ABSTRACT:

Simple Summary

Renal cell carcinoma (RCC) is one of the most common cancer types. However, the lack of clinical symptoms and validated biomarkers for early stage RCC prevent timely disease diagnosis. The study was focused on revealing potential low molecular biomarkers for early-stage RCC. The untargeted direct injection mass spectrometry-based metabolite profiling of blood plasma samples from non-cancer volunteers (control) and RCC patients (early stages of clear cell RCC (ccRCC), papillary RCC (pRCC), chromophobe RCC (chrRCC), and advanced stages of ccRCC) was performed. A set of metabolites with diagnostic power for the early stages of ccRCC was detected.

Abstract

Early diagnostics significantly improves the survival of patients with renal cell carcinoma (RCC), which i

SUBMITTER: Maslov D 

PROVIDER: S-EPMC9818272 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature