Immunotherapy as a Promising Option for the Treatment of Advanced Chordoma: A Systemic Review.

ABSTRACT:

Objective

To summarize the function and efficacy of immunotherapy as an adjunctive therapy in the treatment of advanced chordoma.

Methods

Literature search was conducted by two reviewers independently. Case reports, case series and clinical trials of immunotherapy for chordoma were retrieved systematically from Pubmed, Web of Science, Scoupus and Cochrane Library. Clinical outcome data extracted from the literature included median progression-free survival (PFS), median overall survival (OS), clinical responses and adverse events (AEs).

Results

All studies were published between 2015 and 2022. Twenty-two eligible studies were selected for systemic review. PD-1/PD-L1 immune checkpoint inhibitors (ICIs) were the most common used immunotherapy agents in chordoma, among w

SUBMITTER: Wang X 

PROVIDER: S-EPMC9818311 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature