Serum-Exosome-Derived miRNAs Serve as Promising Biomarkers for HCC Diagnosis.

ABSTRACT:

Background

Serum exosomes are emerging as key liquid biopsy biomarkers for the early diagnosis of cancer. However, the proportion and distribution of small RNA (sRNA) species from serum exosomes of hepatocellular carcinoma (HCC) patients remain unclear. Effective and reliable biomarkers for HCC diagnosis should be explored.

Methods

In this study, we aimed to use sRNA sequencing to profile the sRNAs of serum exosomes in HCC and non-tumor donors. The serum exosomes of 124 HCC patients and 46 non-tumor donors were enrolled for detecting the values of the potential biomarkers for the diagnosis of HCC.

Results

We found that miRNAs accounted for the maximal percentage of all types of sRNAs both in the serum exosomes of HCC patients and non-tumor donors. This indicated that

SUBMITTER: Rui T 

PROVIDER: S-EPMC9818484 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature