Cytotoxic CD8⁺ T Cells Are Involved in the Thrombo-Inflammatory Response during First-Diagnosed Atrial Fibrillation.

ABSTRACT:

Background

Atrial myopathy and atrial fibrillation (AF) accompany thrombo-inflammation. This facilitates disease progression and promotes major adverse cardiovascular events (MACEs). Thrombin receptor (protease-activated receptor 1, PAR1) signalling is central in mediating thrombo-inflammation. We hypothesised that PAR1 signalling links coagulation and inflammation through cytotoxic CD8⁺ T lymphocytes in patients presenting with first-diagnosed AF (FDAF).

Methods

A total of 210 patients were studied. We included data and blood samples from patients presenting with FDAF (n = 160), cardiac tissue from patients with paroxysmal AF (n = 32) and 20 controls.

Results

During early AF, a pro-inflammatory and cytotoxic subset of T lymphocytes (CD8⁺

SUBMITTER: Friebel J 

PROVIDER: S-EPMC9818535 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature