Identification of R-Spondin Gene Signature Predictive of Metastatic Progression in BRAFV^600E-Positive Papillary Thyroid Cancer.

ABSTRACT: Papillary thyroid carcinoma (PTC) is the most common malignancy of the thyroid gland and early stages are curable. However, a subset of PTCs shows an unusually aggressive phenotype with extensive lymph node metastasis and higher incidence of locoregional recurrence. In this study, we investigated a large cohort of PTC cases with an unusual aggressive phenotype using a high-throughput RNA sequencing (RNA-Seq) to identify differentially regulated genes associated with metastatic PTC. All metastatic PTC with mutated BRAF (V600E) but not BRAF wild-type expressed an up-regulation of R-Spondin Protein 4 (RSPO4) concomitant with an upregulation of genes involved in focal adhesion and cell-extracellular matrix signaling. Further immunohistochemistry validation confirmed the upregulation of these t

SUBMITTER: da Silva SD 

PROVIDER: S-EPMC9818556 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature