Ontology highlight
ABSTRACT:
SUBMITTER: Betzler AC
PROVIDER: S-EPMC9818583 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Betzler Annika C AC Strobel Hannah H Abou Kors Tsima T Ezić Jasmin J Lesakova Kristina K Pscheid Ronja R Azoitei Ninel N Sporleder Johanna J Staufenberg Anna-Rebekka AR Drees Robert R Weissinger Stephanie E SE Greve Jens J Doescher Johannes J Theodoraki Marie-Nicole MN Schuler Patrick J PJ Laban Simon S Kibe Toshiro T Kishida Michiko M Kishida Shosei S Idel Christian C Hoffmann Thomas K TK Lavitrano Marialuisa M Grassilli Emanuela E Brunner Cornelia C
Cancers 20230103 1
Here, we describe the expression of Bruton's Tyrosine Kinase (BTK) in head and neck squamous cell carcinoma (HNSCC) cell lines as well as in primary HNSCC samples. BTK is a kinase initially thought to be expressed exclusively in cells of hematopoietic origin. Apart from the 77 kDa BTK isoform expressed in immune cells, particularly in B cells, we identified the 80 kDa and 65 kDa BTK isoforms in HNSCC, recently described as oncogenic. Importantly, we revealed that both isoforms are products of th ...[more]