Prognostic Value of Bladder Involvement in the Outcome of Upper Tract Urothelial Carcinoma.

ABSTRACT: Accurately predicting the clinical prognosis of upper tract urothelial carcinoma (UTUC) seems crucial. We evaluated the effect of the involvement of urothelial bladder carcinoma (UBC) as a potential prognostic factor for overall survival (OS) and progression-free survival (PFS). The cohort included 115 patients with UTUC, subgrouped between January 2009 and December 2019 as follows: (1) only UTUC and (2) UTUC with synchronous or metachronous UBC (UTUC + UBC). Univariate and multivariate analyses were performed to identify independent prognostic factors for OS and PFS. Synchronous or metachronous UBC diagnosis in UTUC patients was an independent predictor of worse PFS (HR 3.326 CI 95% 1.474-7.503, p = 0.004), but it was not identified as a prognostic factor for OS (p > 0.05

SUBMITTER: Meireles S 

PROVIDER: S-EPMC9818601 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature