Clinical Significance of Glycolytic Metabolic Activity in Hepatocellular Carcinoma.

ABSTRACT: High metabolic activity is a hallmark of cancers, including hepatocellular carcinoma (HCC). However, the molecular features of HCC with high metabolic activity contributing to clinical outcomes and the therapeutic implications of these characteristics are poorly understood. We aimed to define the features of HCC with high metabolic activity and uncover its association with response to current therapies. By integrating gene expression data from mouse liver tissues and tumor tissues from HCC patients (n = 1038), we uncovered three metabolically distinct HCC subtypes that differ in clinical outcomes and underlying molecular biology. The high metabolic subtype is characterized by poor survival, the strongest stem cell signature, high genomic instability, activation of EPCAM and SALL4, a

SUBMITTER: Jung J 

PROVIDER: S-EPMC9818850 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature