Long Non-Coding RNAs as Epigenetic Regulators of Immune Checkpoints in Cancer Immunity.

ABSTRACT: In recent years, cancer treatment has undergone significant changes, predominantly in the shift towards immunotherapeutic strategies using immune checkpoint inhibitors. Despite the clinical efficacy of many of these inhibitors, the overall response rate remains modest, and immunotherapies for many cancers have proved ineffective, highlighting the importance of knowing the tumor microenvironment and heterogeneity of each malignancy in patients. Long non-coding RNAs (lncRNAs) have attracted increasing attention for their ability to control various biological processes by targeting different molecular pathways. Some lncRNAs have a regulatory role in immune checkpoints, suggesting they might be utilized as a target for immune checkpoint treatment. The focus of this review is to describe releva

SUBMITTER: Saadi W 

PROVIDER: S-EPMC9819025 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature