Characterization of a Novel Amphiphilic Cationic Chlorin Photosensitizer for Photodynamic Applications.

ABSTRACT: A novel amphiphilic cationic chlorin e₆ derivative was investigated as a promising photosensitizer for photodynamic therapy. Two cationic -N(CH₃)₃⁺ groups on the periphery of the macrocycle provide additional hydrophilization of the molecule and ensure its electrostatic binding to the mitochondrial membranes and bacterial cell walls. The presence of a hydrophobic phytol residue in the same molecule results in its increased affinity towards the phospholipid membranes while decreasing its stability towards aggregation in aqueous media. In organic media, this chlorin e₆ derivative is characterized by a singlet oxygen quantum yield of 55%. Solubilization studies in different polymer- and surfactant-based supramolecular system

SUBMITTER: Gradova MA 

PROVIDER: S-EPMC9820311 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature