Ontology highlight
ABSTRACT:
SUBMITTER: Skelding KA
PROVIDER: S-EPMC9820412 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Skelding Kathryn A KA Barry Daniel L DL Theron Danielle Z DZ Lincz Lisa F LF
International journal of molecular sciences 20221229 1
Acute myeloid leukaemia (AML) is a heterogeneous disease with one of the worst survival rates of all cancers. The bone marrow microenvironment is increasingly being recognised as an important mediator of AML chemoresistance and relapse, supporting leukaemia stem cell survival through interactions among stromal, haematopoietic progenitor and leukaemic cells. Traditional therapies targeting leukaemic cells have failed to improve long term survival rates, and as such, the bone marrow niche has beco ...[more]