Emerging Role of Neutrophil Extracellular Traps in Gastrointestinal Tumors: A Narrative Review.

ABSTRACT: Neutrophil extracellular traps (NETs) are extracellular fibrous networks consisting of depolymerized chromatin DNA skeletons with a variety of antimicrobial proteins. They are secreted by activated neutrophils and play key roles in host defense and immune responses. Gastrointestinal (GI) malignancies are globally known for their high mortality and morbidity. Increasing research suggests that NETs contribute to the progression and metastasis of digestive tract tumors, among them gastric, colon, liver, and pancreatic cancers. This article explores the formation of NETs and reviews the role that NETs play in the gastrointestinal oncologic microenvironment, tumor proliferation and metastasis, tumor-related thrombosis, and surgical stress. At the same time, we analyze the qualitative and quanti

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9820455 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature