CT and MRI Imaging of Theranostic Bimodal Fe₃O₄@Au NanoParticles in Tumor Bearing Mice.

ABSTRACT: Gold-containing nanoparticles are proven to be an effective radiosensitizer in the radiotherapy of tumors. Reliable imaging of nanoparticles in a tumor and surrounding normal tissues is crucial both for diagnostics and for nanoparticle application as radiosensitizers. The Fe₃O₄ core was introduced into gold nanoparticles to form a core/shell structure suitable for MRI imaging. The aim of this study was to assess the in vivo bimodal CT and MRI enhancement ability of novel core/shell Fe₃O₄@Au theranostic nanoparticles. Core/shell Fe₃O₄@Au nanoparticles were synthesized and coated with PEG and glucose. C57Bl/6 mice bearing Ca755 mammary adenocarcinoma tumors received intravenous injections of the nanoparticles. CT and MRI were

SUBMITTER: Lipengolts AA 

PROVIDER: S-EPMC9820463 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature