The Active Site of the Enzyme 10-Formyl-THFDH in the Honey Bee Apis mellifera-A Key Player in Formic Acid Detoxification.

ABSTRACT: Honey bees are important managed pollinators that fulfill important ecological and economic functions. In recent decades, the obligate ectoparasite Varroa destructor severely affected the survival of honey bees, as it weakened them by different means. A common treatment against V. destructor is formic acid fumigation, which has been used for decades by beekeepers across the world. This treatment is known to be effective, but many beekeepers report adverse effects of formic acid on bees, which include damage to the brood, worker bee mortality, and queen loss. Little is known about the molecular mechanisms of formic acid detoxification in honey bees. Recently, we reported upregulation of the bee enzyme, 10-formyl-THFDH, under formic acid fumigation. Here, the active site of thi

SUBMITTER: Mating M 

PROVIDER: S-EPMC9820478 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature