CRISPR/Cas-Based Approaches to Study Schizophrenia and Other Neurodevelopmental Disorders.

ABSTRACT: The study of diseases of the central nervous system (CNS) at the molecular level is challenging because of the complexity of neural circuits and the huge number of specialized cell types. Moreover, genomic association studies have revealed the complex genetic architecture of schizophrenia and other genetically determined mental disorders. Investigating such complex genetic architecture to decipher the molecular basis of CNS pathologies requires the use of high-throughput models such as cells and their derivatives. The time is coming for high-throughput genetic technologies based on CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat)/Cas systems to manipulate multiple genomic targets. CRISPR/Cas systems provide the desired complexity, versatility, and flexibility to create nov

SUBMITTER: Kurishev AO 

PROVIDER: S-EPMC9820593 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature