Regulating Death and Disease: Exploring the Roles of Metacaspases in Plants and Fungi.

ABSTRACT: Identified over twenty years ago and distantly related to animal caspases are a group of cysteine proteases known as metacaspases. Throughout the years, much like caspase roles in metazoans, metacaspases have been shown to be involved in regulating cellular death in non-metazoan organisms. Yet, continued research on metacaspases describes these proteins as intricate and multifunctional, displaying striking diversity on distinct biological functions. In this review, we intend to describe the recent advances in our understanding of the divergence of metacaspase functionality in plants and fungi. We will dissect the duality of metacaspase activity in the context of plant-pathogen interactions, providing a unique lens from which to characterize metacaspases in the development, immunity, and st

SUBMITTER: Garcia N 

PROVIDER: S-EPMC9820594 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature