Biofilm Formation by Staphylococcus aureus in the Specific Context of Cystic Fibrosis.

ABSTRACT: Staphylococcus aureus is a major human pathogen whose characteristics support its success in various clinical settings including Cystic Fibrosis (CF). In CF, S. aureus is indeed the most commonly identified opportunistic pathogen in children and the overall population. S. aureus colonization/infection, either by methicillin-susceptible or methicillin-resistant strains, will become chronic in about one third of CF patients. The persistence of S. aureus in CF patients' lungs, despite various eradication strategies, is favored by several traits in both host and pathogen. Among the latter, living in biofilm is a highly protective way to survive despite deleterious environmental conditions, and is a common characteristic shared by the main pathogens identified in CF.

SUBMITTER: Jean-Pierre V 

PROVIDER: S-EPMC9820612 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature