Lipoprotein(a): Cardiovascular Disease, Aortic Stenosis and New Therapeutic Option.

ABSTRACT: Atherosclerosis is a chronic and progressive inflammatory process beginning early in life with late clinical manifestation. This slow pathological trend underlines the importance to early identify high-risk patients and to treat intensively risk factors to prevent the onset and/or the progression of atherosclerotic lesions. In addition to the common Cardiovascular (CV) risk factors, new markers able to increase the risk of CV disease have been identified. Among them, high levels of Lipoprotein(a)-Lp(a)-lead to very high risk of future CV diseases; this relationship has been well demonstrated in epidemiological, mendelian randomization and genome-wide association studies as well as in meta-analyses. Recently, new aspects have been identified, such as its association with aortic stenosis. Al

SUBMITTER: Maloberti A 

PROVIDER: S-EPMC9820656 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature