Ontology highlight
ABSTRACT:
SUBMITTER: Lin ZH
PROVIDER: S-EPMC9820670 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Lin Zhi-Han ZH Chang Shun-Ya SY Shen Wen-Chi WC Lin Yen-Hung YH Shen Chiu-Lun CL Liao Sin-Bo SB Liu Yu-Chun YC Chen Chang-Shi CS Ching Tsui-Ting TT Wang Horng-Dar HD
International journal of molecular sciences 20221229 1
Altered metabolism is a hallmark of aging. The tricarboxylic acid cycle (TCA cycle) is an essential metabolic pathway and plays an important role in lifespan regulation. Supplementation of α-ketoglutarate, a metabolite converted by <i>isocitrate dehydrogenase alpha-1</i> (<i>idha-1</i>) in the TCA cycle, increases lifespan in <i>C. elegans</i>. However, whether <i>idha-1</i> can regulate lifespan in <i>C. elegans</i> remains unknown. Here, we reported that the expression of <i>idha-1</i> modulat ...[more]