Multimodal phenotyping and correlates of pain following hematopoietic cell transplant in children with sickle cell disease.

ABSTRACT:

Introduction

There is limited understanding of pain, patient-reported outcomes (PROs) of health-related quality of life (HRQoL), psychological factors, and experimental pain sensitivity before and following hematopoietic cell transplant (HCT) in children with sickle cell disease (SCD).

Methods

Individuals aged 8 years and older, English speaking, and scheduled for a HCT were invited to participate in an observational study where they completed assessments of pain, PROs, psychological factors, and qualitative interviews before and around 3 months, 6 months, 1 year, and 2 years post-HCT. An optional substudy of experimental pain sensitivity before and around 6 month, 1 year, and 2 years post-HCT was also offered.

Results

Data from eight participants (median age 13.5 yea

SUBMITTER: Bakshi N 

PROVIDER: S-EPMC9820671 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature