Understanding the Biophysical Interaction of LTX-315 with Tumoral Model Membranes.

ABSTRACT: Host defense peptides are found primarily as natural antimicrobial agents among all lifeforms. These peptides and their synthetic derivatives have been extensively studied for their potential use as therapeutic agents. The most accepted mechanism of action of these peptides is related to a nonspecific mechanism associated with their interaction with the negatively charged groups present in membranes, inducing bilayer destabilization and cell death through several routes. Among the most recently reported peptides, LTX-315 has emerged as an important oncolytic peptide that is currently in several clinical trials against different cancer types. However, there is a lack of biophysical studies regarding LTX-315 and its interaction with membranes. This research focuses primarily on the understan

SUBMITTER: Klaiss-Luna MC 

PROVIDER: S-EPMC9820754 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature