Application of Various Techniques to Gain Insights Into the Complex Urinary Tract Microbial Communities of Renal Transplant Recipients.

ABSTRACT: Urinary tract infections (UTIs) are prevalent in renal transplant (RT_X) recipients and associated with worse outcomes. Early detection by sensitive diagnostic tests and appropriate treatment strategies in this cohort is therefore crucial, but evidence has shown that current methods may miss genuine infections. Research has shed light on the urinary tract microbial ecology of healthy individuals and nontransplant patients with UTI, but information on the RTx cohort is scant. We conducted a cross-sectional study to (i) compare the gold standard diagnostic culture with alternative techniques and (ii) characterize RTx patient urinary microbial communities.

Methods

Midstream urine specimens were collected from 51 RTx patients attending a renal transplant clinic and 27 asymptom

SUBMITTER: Sathiananthamoorthy S 

PROVIDER: S-EPMC9820791 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature