Image-based computer modeling assessment of microwave ablation for treatment of adrenal tumors.

ABSTRACT:

Purpose

To assess the feasibility of delivering microwave ablation for targeted treatment of aldosterone producing adenomas using image-based computational models.

Methods

We curated an anonymized dataset of diagnostic ¹¹C-metomidate PET/CT images of 14 patients with aldosterone producing adenomas (APA). A semi-automated approach was developed to segment the APA, adrenal gland, and adjacent organs within 2 cm of the APA boundary. The segmented volumes were used to implement patient-specific 3D electromagnetic-bioheat transfer models of microwave ablation with a 2.45 GHz directional microwave ablation applicator. Ablation profiles were quantitatively assessed based on the extent of the APA target encompassed by an ablative thermal dose, while limiting thermal damag

SUBMITTER: Sebek J 

PROVIDER: S-EPMC9820798 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature