Application of Antimicrobial Photodynamic Therapy for Inactivation of Acinetobacter baumannii Biofilms.

ABSTRACT: Acinetobacter baumannii is a dangerous hospital pathogen primarily due to its ability to form biofilms on different abiotic and biotic surfaces. The present study investigated the effect of riboflavin- and chlorophyllin-based antimicrobial photodynamic therapy, performed with near-ultraviolet or blue light on the viability of bacterial cells in biofilms and their structural stability, also determining the extent of photoinduced generation of intracellular reactive oxygen species as well as the ability of A. baumannii to form biofilms after the treatment. The efficacy of antimicrobial photodynamic therapy was compared with that of light alone and the role of the photosensitizer type on the photosensitization mechanism was demonstrated. We found that the antibacterial effect of

SUBMITTER: Buchovec I 

PROVIDER: S-EPMC9820809 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature