Neonatal Hepatic Myeloid Progenitors Expand and Propagate Liver Injury in Mice.

ABSTRACT:

Background

Biliary atresia (BA) is a progressive pediatric inflammatory disease of the liver that leads to cirrhosis and necessitates liver transplantation. The rapid progression from liver injury to liver failure in children with BA suggests that factors specific to the perinatal hepatic environment are important for disease propagation. Hematopoietic stem and progenitor cells (HSPCs) reside in the fetal liver and are known to serve as central hubs of inflammation. We hypothesized that HSPCs are critical for the propagation of perinatal liver injury (PLI).

Methods

Newborn BALB/c mice were injected with rhesus rotavirus (RRV) to induce PLI or with PBS as control. Livers were compared using histology and flow cytometry. To determine the effects of HSPCs on PLI, RRV-infected n

SUBMITTER: Alkhani A 

PROVIDER: S-EPMC9821039 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature