Differential Diagnosis of Hyperferritinemia in Critically Ill Patients.

ABSTRACT:

Background

Elevated serum ferritin is a common condition in critically ill patients. It is well known that hyperferritinemia constitutes a good biomarker for hemophagocytic lymphohistiocytosis (HLH) in critically ill patients. However, further differential diagnoses of hyperferritinemia in adult critically ill patients remain poorly investigated. We sought to systematically investigate hyperferritinemia in adult critically ill patients without HLH.

Methods

In this secondary analysis of a retrospective observational study, patients ≥18 years admitted to at least one adult intensive care unit at Charité-Universitätsmedizin Berlin between January 2006 and August 2018, and with hyperferritinemia of ≥500 μg/L were included. Patients with HLH were excluded. All patients were categ

SUBMITTER: Schuster FS 

PROVIDER: S-EPMC9821140 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature