Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases.

ABSTRACT: Redox regulation participates in the control of various aspects of metabolism. Reactive oxygen and nitrogen species participate in many reactions under physiological conditions. When these species overcome the antioxidant defense system, a distressed status emerges, increasing biomolecular damage and leading to functional alterations. Air pollution is one of the exogenous sources of reactive oxygen and nitrogen species. Ambient airborne particulate matter (PM) is important because of its complex composition, which includes transition metals and organic compounds. Once in contact with the lungs' epithelium, PM components initiate the synthesis of inflammatory mediators, macrophage activation, modulation of gene expression, and the activation of transcription factors, which are all related t

SUBMITTER: Sierra-Vargas MP 

PROVIDER: S-EPMC9821141 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature